EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.63 | medicine | O4-benzylfolic acid is 30times more active than O6-benzylguanine against the wild-type alkyltransferase, inactivation of P140K mutant alkyltransferase. Inhibitor shows promise as an agent for possible tumor-selective alkyltransferase inactivation superior toO6-benzylguanine as a chemotherapy adjuvant | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.63 | 2-amino-O4-benzyl-6,7-dimethylpteridine | potent | Homo sapiens | |
2.1.1.63 | 2-amino-O4-benzyl-6-formylpteridine | potent | Homo sapiens | |
2.1.1.63 | 2-amino-O4-benzyl-6-hydroxymethylpteridine | potent | Homo sapiens | |
2.1.1.63 | 2-amino-O4-benzylpteridine | potent | Homo sapiens | |
2.1.1.63 | 2-amino-O4-benzylpteridine-6-carboxylic acid | potent | Homo sapiens | |
2.1.1.63 | O4-benzylfolic acid | 30times more active than O6-benzylguanine against the wild-type alkyltransferase, inactivation of P140K mutant alkyltransferase. Inhibitor shows promise as an agent for possible tumor-selective alkyltransferase inactivation superior toO6-benzylguanine as a chemotherapy adjuvant | Homo sapiens | |
2.1.1.63 | O6-benzylguanine | potent inhibitor of wild-type enzyme, no inactivation of mutant enzyme P140K | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.63 | Homo sapiens | - |
- |
- |